CCND1 and neoplasm: Compared to the control, the protein expression levels of STAT3, p-STAT3Ser727, p-STAT3Tyr705, Bcl2, cyclin D1, and c-myc were lower in the Stattic and CTS-treated groups (Figures 4Ca–f), indicating that STAT3 might be important for tumor development and progression in TA2 SBC.