In MM cells, through binding to cereblon (CRBN), an adaptor protein of the Cul4A-DDB1-ROC1 ubiquitin E3 ligase complex, they induce proteasomal degradation of the lymphoid transcription factors IKAROS family zinc finger 1 (IKZF1), AIOLOS (IKZF3) (43, 44) and casein kinase 1α (CK1α) (45) leading to the transcriptional repression of the interferon regulatory factor 4 (IRF4) and MYC. Here, CRBN is linked to Miyoshi myopathy.