CTLA4 and Miyoshi myopathy: As such, they have showed that the T-cells presented a senescent secretory effector phenotype characterized by positive killer cell lectine like receptor (KLRG-1+)/CD57+/CD160+/CD28− and low programmed death 1 (PD1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) expression, proposing that in MM the T-cells have a molecular signature of senescence rather than exhaustion (36).