PTRH2 and lung carcinoma: Yao et al. conducted a series of studies on TLE1 in lung cancer that proved TLE1 was an oncogene that not only sequestered mitochondrial BCL-2 inhibitor of transcription 1 (BIT1) in the nucleus, thereby blocking the anoikis function of BIT1, but also enhanced EMT through ZEB1-mediated E-cadherin repression (27, 28).