TSC2 and hepatocellular carcinoma: However, several genes were found to be mutated in other pediatric tumors in these databases, such as CTNNB1, DEPDC5, ERBB4, EGFR, CEP164, and CX3CL1. The only sample classified as subtype HB/HCC features carries alterations in genes found to be mutated in HCCs (TSC2, HMCN1, UNC80, VPS13B, and TERT promoter), corroborating the histological classification because the mutational load resembles hepatic tumors with more differentiated cells.