Moreover, this gene set was enriched among gene sets from other cancers: EGFR-KRAS-ALK–negative lung adenocarcinoma in never-smokers (CFTR, CTNNB1, EGFR, ERBB4, MXRA5, TGFBR2) (42), bladder cancer (EGFR, ERBB4, FLCN, PIK3R1, TSC2) (43), and metastatic renal cell carcinoma (DEPDC5, EGFR, FLCN, PIK3R1, TSC2) (44), suggesting they could have a broader role in cancer. Here, MXRA5 is linked to urinary bladder cancer.