TG and cancer: STRING (40) analysis using the 87 mutated genes as seeds and whole genome as background (with all types of evidences with a minimum confidence level of 0.4) revealed an enriched protein–protein interaction network (p = 2e-5) involved with some cancers (colorectal, prostate, and endometrial), signaling pathways (thyroid hormone, ErbB, AMPK), adherens junction, choline metabolism in cancer, and proteoglycans in cancer (FDR <0.05, KEGG; Supplementary Figure 1).