Three genes, which we have previously reported as differentially methylated in HBs (41), were mutated in the present cohort, reinforcing a possible role in HB tumorigenesis: EGFR, LMBRD1, and AHRR. LMBRD1 encodes a lysosomal membrane protein and is associated with a vitamin B12 metabolism disorder (48), and AHRR and EGFR are involved in regulation of cell growth and differentiation. This evidence concerns the gene LMBRD1 and hemoglobin measurement.