The clinical immune evaluation studies in metastatic breast cancer, metastatic prostate cancer, non-Hodgkin's lymphoma and MM showed the induction of Th1 cytokine patterns with elevated levels of IFN-γ, TNF-α, GM-CSF, and IL-12 in the patients with increases in IP-10, and decreases in IL-8 (5, 6, 10, 18). Here, TNF is linked to metastatic prostate carcinoma.