We found that this sensor influences the formation of hepatic granuloma, altering local chemokine (CCL2, CCL3, and CXCL1) and cytokine (IL-5, IL-10, and IL-13) production, macrophage and neutrophil recruitment into the liver, and also is important for promoting collagen deposition. The gene discussed is CXCL1; the disease is hepatic granuloma.