In addition to C1-INH-HAE, studying the activation of the plasma enzyme systems controlled by C1-INH is also important in other conditions (e.g., sepsis, cardiopulmonary bypass, SLE, and polytrauma), and has already been undertaken, although by monitoring fewer parameters (40, 44, 45, 53). The gene discussed is SERPING1; the disease is systemic lupus erythematosus.