CD4 and Sepsis: Hence, in the process of Candida sepsis, T-bet acts on CD4+ T cells to regulate the differentiation and growth of its effector cells, thus participating in the clearance of disseminated Candida. In this research, we found that T-bet expression increased after infection but decreased with aggravation of sepsis, suggesting that T-bet plays an important role in the regulation of CD4+ T cells during lethal Candida sepsis.