Some PSEN1 mutations have also been reported in patients with other diseases, including frontotemporal dementia, dementia with Lewy bodies, Pick's disease, cerebral amyloid angiopathy, subcortical dementia, amyotrophic lateral sclerosis, progressive non-fluent aphasia, dilated cardiomyopathy, and familial acne inversa (http://www.alzforum.org/mutations/search? genes[]=493). Here, PSEN1 is linked to frontotemporal dementia.