LGI1 and Hyponatremia: For seizures, broad-spectrum AEDs such as LEV, VPA, TPM, and benzodiazepines were suitable; sodium-channel blockers such as oxcarbazepine and carbamazepine were not recommended because of high incidence of specific cutaneous adverse reaction and hyponatremia (already present in a subset of patients due to a concomitant syndrome of inappropriate antidiuretic hormone secretion) in patients with LGI1 AE (2).