SFTPC and newborn respiratory distress syndrome: However, reduced transcription of SFTPC due to promotor variant were associated with neonatal respiratory distress syndrome in late preterm infants (Wambach et al., 2010) and SP-C was absent in BALF samples of a family with chronic ILDs, together with reduced pro-SP-C staining, though no mutation was identified (Amin et al., 2001).