The relevance of inflammasome activation and IL-1β signaling in fibrotic parenchyma remodeling has been shown for silica induced- ILDs (Cassel et al., 2008), bleomycin-induced lung fibrosis (Gasse et al., 2007) and various other organ systems (Vilaysane et al., 2010; Wree et al., 2014; Lv et al., 2018). The gene discussed is IL1B; the disease is pulmonary fibrosis.