Cholesterol clefts are present in aging 129/Sv4 mice (Hoenerhoff et al., 2006), SP-C deficient mice (Glasser et al., 2003; Ruwisch et al., 2020) or aaAMs in human herpes virus (HHV)-induced lung fibrosis (Mora et al., 2006). The gene discussed is SFTPC; the disease is pulmonary fibrosis.