Besides to AE2C hyperplasia, cholesterol clefts are frequently detected on lung biopsy in context of an SFTPC mutations (Hamvas et al., 2004; Abou Taam et al., 2009; Mechri et al., 2010; Cottin et al., 2011; Litao et al., 2017) or on lung specimen from ILD patients lacking SP-C (Amin et al., 2001). This evidence concerns the gene SFTPC and interstitial lung disease.