SFTPC and interstitial lung disease: Curiously, SP-C deficient mice as well as patients suffering mutant SP-C derived interstitial lung diseases (ILDs) related to mutations of SP-C, showed similar foamy macrophages in BALF and tissue as well as abundant cholesterol clefts (Glasser et al., 2003; Hamvas et al., 2004; Abou Taam et al., 2009; Ruwisch et al., 2020).