SFTPC and lung disorder: Increased uptake of SA by AMs in combination with SP-C disrupted cholesterol metabolism, which may partly explain the presence of foamy macrophages in the SP-C deficient lung and lung diseases related to SP-C mutated forms (Glasser et al., 2003; Hamvas et al., 2004; Lawson et al., 2004; Stevens et al., 2005; Henderson et al., 2013; Liptzin et al., 2015; Salerno et al., 2016).