SFTPC and lung disorder: The finding of cholesterol clefts and lipid laden macrophages in patients with SP-C mutations suggests impaired cholesterol homeostasis to be of relevance for development of lung disease in these patients (Hamvas et al., 2004; Abou Taam et al., 2009; Mechri et al., 2010; Cottin and Cordier, 2011; Litao et al., 2017).