The two primary neuropathological hallmarks of AD, deposition of Aβ and abundant neurons with hyperphosphorylated tau (Iqbal et al., 2009; Crews and Masliah, 2010; Vinters, 2015), are increased with age in 3xTg-AD mice (Oddo et al., 2003). This evidence concerns the gene MAPT and Alzheimer disease.