With that said, drugs that modulate GSK3β (Lee et al., 2011b; Emamian, 2012; Bhat et al., 2018) and Erk1/2 (Lu and Dwyer, 2005; Pereira et al., 2014; Tassin et al., 2015; Aringhieri et al., 2017; Hirayama-Kurogi et al., 2017) have shown significant promise in treating synaptic and behavioral defects of schizophrenia, depression, and bipolar disorder. The gene discussed is GSK3B; the disease is schizophrenia.