TIMP1 and Cognitive impairment: And the ordinal analysis suggested significant associations between serum TIMP‐1 and cognitive impairment severity, the ORs were 1.58 (95% CI, 1.01‐2.48; P trend = 0.020) for MMSE and 1.67 (95% CI, 1.07‐2.61; P trend = 0.008) for MoCA, when two extreme quartiles were compared (Figure 2).