TIMP1 and Cognitive impairment: After further adjustment for clinical features, medical histories and other covariates in model 3, compared with the lowest quartile of TIMP‐1, the ORs for the highest quartile were 1.80 (95% CI, 1.09‐2.97) for cognitive impairment defined by MMSE and 2.55 (95% CI, 1.49‐4.35) by MoCA.