Adding serum TIMP‐1 to the conventional models improved risk reclassification for cognitive impairment, as evidenced by an increase in NRI of 0.191 (95% CI, 0.034‐0.349; P = 0.020), IDI of 0.012 (95% CI, 0.004‐0.021; P = 0.005) for cognitive impairment was defined by MMSE; and NRI of 0.273 (95% CI, 0.109‐0.437; P = 0.001), IDI of 0.026 (95% CI, 0.013‐0.039; P < 0.001) for MoCA. The gene discussed is TIMP1; the disease is Cognitive impairment.