As we have shown that there are only little molecular genetic differences in the tumor genome of the ambiguous AST category in comparison with the group of highly aggressive MST, one may speculate that the environmental immunologic neighborhood hosting the Spitzoid melanocytic neoplasms might define the lesion’s biological behavior with either arrest of metastatic potential in the locoregional lymph node or development of distant metastasis. Here, GOT1 is linked to neoplasm.