F8 and hyperinsulinemic hypoglycemia, familial, 4: In either case, findings obtained after exclusion of HBV/HCV-positive patients and further restricting our analysis to patients with severe haemophilia A and no clinical evidence for significant arthropathy do not support the concept that inherited FVIII deficiency per se is associated with boosted LPS-induced monocyte TF production (Online Resource 8), which rather results from an inflammatory environment triggered, for instance, by blood-induced joint disease and/or HBV/HCV infections (Fig. 6).