In summary, we provide novel evidence that patients with moderate-to-severe haemophilia show boosted TF expression and release by whole-blood monocytes in response to LPS, a finding predominantly observed in patients with a positive HBV/HCV infection status and clinically significant arthropathy and consistent with our previous observation that ADP-induced platelet PDI expression positively correlated with age in patients with haemophilia A [19]. This evidence concerns the gene TF and hemophilia A.