TF and hemophilia A: We have previously shown that agonist-induced expression and release of platelet protein disulphide isomerase (PDI), an abundant pro-inflammatory and thrombogenic oxidoreductase involved in TF activation on monocytes/macrophages, are increased in patients with haemophilia A [19], pointing to a potential role of platelet PDI as an injury response signal under conditions of defective thrombin generation.