F2 and COVID-19: Significantly higher levels of D-dimer and fibrin degradation products, along with longer prothrombin and activated thromboplastin times were observed in SARS-CoV-2-infected subjects who did not survive, with the 71.4% frequency of DIC in non-survivors and 0.6% in survivors highlighting the critical role played by such condition in COVID-19 severity and associated deaths [23].