Studies on IGF have shown that it is involved in the migration of human arterial smooth muscle cells (SMCs) [38]; production of nitric oxide in endothelial cells [39, 40]; and some vascular diseases, such as stenotic arteriovenous fistula [41], coronary arteriosclerosis [42], carotid artery intima-media thickening [43] and ischaemic heart disease [44]. The gene discussed is IGF1; the disease is heart disorder.