In tumor tissues, circ-001971 and VEGFA expression was significantly increased whereas miR-29c-3p expression was reduced, further suggesting that circ-001971 counteracts miR-29c-3p-induced inhibition of VEGFA by acting as a ceRNA, therefore aggravating CRC growth, metastasis, and angiogenesis. The gene discussed is VEGFA; the disease is colorectal carcinoma.