One possible mechanism can be proposed to explain the relationship between the Trp64Arg variant and abnormal adipokines levels: The mutation C allele of ADRB3 results in low mRNA expression levels [38] and low protein activity [39] of hormone-sensitive lipase (HSL), the reduce lipase concentration and protein activity will no doubt initiate or accelerate obesity [30–32]. The gene discussed is LIPE; the disease is obesity due to melanocortin 4 receptor deficiency.