Gene annotation enrichment analysis showed that differentially expressed genes were significantly enriched in pathways in cancer, chemokine signaling pathway, TNF signaling pathway and PI3K-Akt signaling pathway based on KEGG analysis, as well as epithelial to mesenchymal transition (EMT), cell adhesion, angiogenesis, cell chemotaxis, inflammatory response, chemotaxis and proteolysis based on GO analysis. The gene discussed is AKT1; the disease is cancer.