Notably, MAKV-8 exposure also enhanced α-tubulin and histone H4 acetylation in KBM-5 and MEG-01 cells, which generalized our findings concerning MAKV-8-mediated inhibition of multiple HDAC activities in CML cells (Fig. 3e). This evidence concerns the gene HDAC9 and chronic myelogenous leukemia, BCR-ABL1 positive.