As LASS2, LASS4 and LASS6 were found to be significantly correlated with Cer-16, Cer-18, Cer-20, Cer-24 and Cer-24:1 in breast cancer tissue [47], it was supposed that ovariectomy had an effect on these long- and ultralong-chain-ceramides in the aorta. The gene discussed is CERS4; the disease is breast carcinoma.