NUCLEOLIN and early-onset autosomal dominant Alzheimer disease: Recently, whole-exome sequencing of Alzheimer’s disease families revealed a missense variant in CLN5 that segregated with Alzhemier’s disease, which supports the hypothesis that there may be similarities between NCL pathology and other forms of neurodegeneration, including Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia [80, 83, 92, 98, 99].