Recently, whole-exome sequencing of Alzheimer’s disease families revealed a missense variant in CLN5 that segregated with Alzhemier’s disease, which supports the hypothesis that there may be similarities between NCL pathology and other forms of neurodegeneration, including Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia [80, 83, 92, 98, 99]. This evidence concerns the gene CLN5 and early-onset autosomal dominant Alzheimer disease.