In addition to ERα-36, large tumor size (HR = 1.84, 95%CI 1.04–3.28, p = 0.04) and high SBR grade (HR = 2.04, 95%CI 1.2–3.5, p = 0.008) were also an independent predictor of poor DMFS in the same multivariate model. This evidence concerns the gene ESR1 and neoplasm.