Because of better knowledge of nosology and biology of lymphomas, new targeted drugs have been developed, including pralatrexate and romidepsin, crizotinib for ALK-positive ALCL, and brentuximab vedotin for CD30-positive PTCL with promising response rate, although the impact on long-term disease control remains unclear [5, 6]. This evidence concerns the gene TNFRSF8 and mature T-cell and NK-cell non-Hodgkin lymphoma.