The strongest positive univariate associations between hypoglycaemia and patient characteristics were found for (Table 4): 1) having had an ED attendance for hypoglycaemia in 2014 (17.3% of subjects experiencing hypoglycaemia vs. 1.2% among subjects without ED attendances); 2) being treated with insulin (4.1% among those treated with insulin alone and 2.7% among those treated also with other anti-DM drugs vs. 0.2% for non-insulin anti-DM not at risk for hypoglycaemia); 3) having chronic renal failure (3.4% vs. 1.1% among subjects without CKD). The gene discussed is INS; the disease is diabetes mellitus.