INS and diabetes mellitus: At the same time, the use of insulin, alone or with other anti-DM drugs, increased the frequency of events compared to being treated only with non-insulin anti-DM drugs not at risk for hypoglycaemia (IRR = 7.72, 95% CI = 5.11–11.66 for insulin alone and IRR = 8.01, 95% CI = 5.21–12.32 for insulin with other anti-DM drugs).