ALKBH5 and pachyonychia congenita: To further illuminate the influence of ALKBH5 on the proliferative responses and invasive activity of PC cells, we performed an RNA-seq assay and found significant transcriptome alterations in which the differentially upregulated expressed genes involved in cell cycle arrest, apoptotic process and negative regulation of cell proliferation after ALKBH5 overexpression in BxPC-3 cells.