ALKBH5 and neoplasm: When compared to PC cells with low-level ALKBH5 expression (BxPC-3/vector group, SW1990/shALKBH5 group), we found a dramatically decreased tumour volume in groups of the BxPC-3/Lv-ALKBH5 and SW1990/scramble (Fig. 4a, c, d, f).