In human studies, it has been found that polymorphisms in Fetuin-A were related to T2DM [17] and circulating Fetuin-A levels are elevated or decreased, or unchanged in obese patients, T2DM, non- alcoholic fatty liver disease (NAFLD), MetS, PCOS and CVD, and are either associated with or not associated with impaired glucose tolerance and IR [18–24]. The gene discussed is AHSG; the disease is metabolic dysfunction-associated steatotic liver disease.