We noticed that T allele representation was increased in all models of MMP-9 (C1562T) SNP comparison in the overall analysis, including dominant model (OR = 1.41, 95% CI = 1.23–1.61, P < 0.001), recessive model (OR = 1.59, 95% CI = 1.29–1.96, P < 0.001), allelic model (OR = 1.38, 95% CI = 1.23–1.55, P < 0.001), TT vs. CC model (OR = 1.70, 95% CI = 1.35–2.13, P < 0.001), and CT vs. CC model (OR = 1.35, 95% CI = 1.18–1.54, P < 0.001), which was associated with an increased risk of CAD significantly. Here, MMP9 is linked to coronary artery disorder.