FOXO1 and Insulin resistance: 2 TNF-α upregulates Angptl2 expression through the Foxo1 pathway, further promoting inflammatory mediators expression and insulin resistance occurence [23].Nevertheless, lentiviral-mediated siRNA interference with the Foxo1 gene can inhibit the transcriptional activity of the Angptl2 promoter, and reduce the adipocyte Angptl2 expression induced by TNF-α [32].