NTRK2 and memory impairment: 2016). In addition, P. tenuifolia extract can also promote the nerve growth factor release in astroglial cells (Yabe et al. 2003). PGS32 significantly increased BDNF content by up-regulation the phosphorylation of ERK, CREB and synapsin I (Xue et al. 2009). PGS32 can also ameliorate against scopolamine-induced memory impairments in AD mice model via up-regulating the level of the p-TrkB, enhanced high frequency stimulation-induced long-term potentiation in the dentate gyrus of rats, and protecting of neurons from damage caused by glutamate and ROS (Zhou et al. 2016).