HDAC8 and neoplasm: However, in the TNBC group, a significant association was found between the increased HDAC8 expression and tumor characteristics, including tumor size (p = 0.039; Fig. 3A), lymphatic invasion (p = 0.01, Fig. 3B), tumor grade (p = 0.02; Fig. 3C), and perineural invasion ( (p = 0.014; Fig. 3D).