Interestingly, the remaining cases (nearly 15%) of colon cancer, which lack APC mutations, carry genetic or epigenetic changes in some other components of the Wnt/β-Catenin signaling pathway (like the genes encoding Axin, β-Catenin, and sFRP)[60 ▶-63 ▶]. Here, APC is linked to malignant colon neoplasm.