Against the background of moderately high blood pressure, OXYS rats spontaneously develop cataract, hypertrophic cardiomyopathy, sarcopenia, osteoporosis, AMD-like retinopathy, and AD-like pathology in the absence of mutations in genes (App, Psen1, and Psen2) that are specific for the familial form of AD [9,10]. Here, APP is linked to Alzheimer disease.