Similarly, the anti-inflammatory molecule 17β-estradiol improved the motoneurons survival in SOD1G93A and reduced the NLRP3 inflammasome in the spinal cord of these mice, especially caspase-1 and IL-1β, suggesting the potential beneficial effect of modulating NLRP3 inflammasome in ALS [43]. The gene discussed is CASP1; the disease is amyotrophic lateral sclerosis.