Both MM and BMSCs cells, apart from the above-mentioned cytokines, can also secrete other factors like vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF-1), TGF-β, angiopoietin-1 (Ang-1), platelet-derived growth factor (PDGF), and basic-fibroblast growth factor (bFGF) [40,41], which have been seen to be associated with increased angiogenesis, osteoclastogenesis, and tumor growth in MM [42]. This evidence concerns the gene ANGPT1 and neoplasm.