NEFL and amyotrophic lateral sclerosis: As TDP-43 mutations are known to induce ALS clinical traits through the mis-splicing of mRNA [40,41,42,43,44] and considering that it has been shown to directly bind to human Nefl mRNA at its 3′UTR [39], we aimed to determine if neflb splicing occurs in the case of a morpholino-driven TDP-43 depletion, which is a well-characterized zebrafish model of ALS [48].