TARDBP and amyotrophic lateral sclerosis: The evidence of a pathological dysregulation of the NEFL expression in ALS is strengthened by the existence of direct interactions between the NEFL mRNA and several ALS-causing proteins [34,35,36,37,38], including TDP-43 (TAR DNA-binding protein 43, encoded by the gene TARDBP), which has been shown to directly bind the human Nefl mRNA at its 3′UTR [39], and to induce ALS clinical traits through the mis-splicing of mRNA [40,41,42,43,44].