NFE2L2 and metabolic dysfunction-associated steatotic liver disease: Of interest, two Nrf2 pathway genes, implicated in the cellular stress-induced antioxidant response, and more specifically MGST1, which regulates inflammatory eicosanoid responses, was upregulated, and GSTA5, which catalyzes glutathione conjugation, was downregulated in NAFLD [48] (Figure 1C,E).