Taken together, it is reasonable to speculate that elevations in Nrf2 transcriptional events are compensatory events to modulate the anti-oxidant stress responses in NASH, while the decrease in the energy-sensor AMPK expression, or activity, leads to a direct exacerbation of NASH pathology, which can be diminished by Lip-C6. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatohepatitis.