BRCA1 and ovarian carcinoma: Two new homo-aza-steroidal alkylating ester compounds (e.g., ENGA-L06E and ENGA-L08E) were tested in an in vitro model of human ovarian carcinoma (consisting of five cell lines namely UWB1.289, UWB1.289+BRCA1, SK-OV-3, OVCAR-5, and OVCAR-3) as well as an in vivo model consisting of SK-OV-3 and OVCAR-5 tumor xenografts.