We examined how RB1, TERT, E2F1, E2F2, and E2F3 gene expressions linked to event-free survival (EFS) in stage 4S NB patients using gene expressions in the publicly available datasets consisting of primary tumor samples from three independent NB patient cohorts (Kocak-649 [26], Oberthuer-251 [27], and SEQC-RPM [28] datasets), downloaded from the R2: Genomic Analysis and Visualization Platform (available online: http://r2.amc.nl). This evidence concerns the gene E2F3 and neoplasm.