Numerous studies proved the efficacy of SGLT-2 inhibitors; probably the most cited being EMPAREG-OUTCOME that proved that empagliflozin administration, in T2DM patients and cardiovascular pathology, reduced the cardiovascular mortality by 38% (HR: 0.62; 95% CI: 0.49–0.77; p < 0.001) [86]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.