P2RX7 and epilepsy: Blockers of P2X7 receptors, i.e., Brilliant Blue G, AFC-5128, JNJ-47965567, tanshinone IIA sulfonate, and A-438079, provided moderate to meaningful antiseizure effect in the experimental models of epilepsy [75,77,78], although they showed only modest anticonvulsant effects on acute convulsions in rodents [77,78].