PCSK9 and myocardial infarction: In the context of the reciprocal regulating relation between long chain n-3 PUFAs and PCSK9, there has recently observed a significant interaction between the common PCSK9 variant rs11206510 located in the promoter region of the PCSK9 gene, identified for early onset myocardial infarction (MI) through a genome-wide association study (GWAS) [172], and long chain n-3 PUFA intake in Costa Rican Hispanics.