Second, the possible underlying inflammatory and antioxidant status linking PREDIMED score, 25OHD levels, and obesity, should be better investigated by measuring both serum inflammatory and antioxidant biomarkers, such as IL-6, c-reactive protein levels, superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde; thus, our hypothesis of a synergistic effect of adherence to the MD and 25OHD levels on obesity remains largely speculative. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.