Furthermore, trehalose intake increased heat shock protein 90 (HSP90) and sigma non-opioid intracellular receptor 1 (SigmaR1) chaperones along with autophagy induction in a mouse model of Lewy body disease (LBD) [22], and preserved proteasome activity to reduce ubiquitin-labeled protein aggregates in a rat model of transient global ischemia [23]. This evidence concerns the gene SIGMAR1 and Lewy body dementia.