The pro-oncogenic function of NCoR-HDAC3 complex was first documented in pro-myelocytic leukemia-retinoic acid receptor-α (PML-RARα), pro-myelocytic leukemia zinc-finger retinoic acid receptor α (PLZF-RARα), and AML1-ETO leukemias. The gene discussed is RARA; the disease is leukemia.