Between groups of MM patients who presented with or without GlcSph-reactive Igs (non-clonal or monoclonal) in serum, no significant difference was found in sex ratio, age at the time of diagnosis, amount of monoclonal Ig, presence of bone lesions, β2-microglobulin, ISS or DSS scores, calcemia, creatinin, or blood counts (leukocytes, platelets, red blood cells, hemoglobin level). This evidence concerns the gene CUBN and Miyoshi myopathy.