Unlike the ones listed above, these trials yielded dampening results: although DAP10 signaling is a strong trigger of cytotoxicity in native NK cells [200,201], those CARs induced weaker anti-tumor activity in direct comparison to receptors containing CD3ζ alone, respectively 4-1BB/CD3ζ or CD28/CD3ζ [166,202]. Here, HCST is linked to neoplasm.