Upon KMT3C silencing, there was diminished proliferative ability and cell cycle arrest at the G0/G1 phase [50], whereas KMT3E silencing induced a decrease in proliferation, migration and invasion of oesophageal cancer cell lines and inhibition of tumour invasion in vivo, as well as up-regulation of KMT8 mRNA and protein levels [51,52]. This evidence concerns the gene SMYD2 and carcinoma of esophagus.