Upon UBE2C silencing there was a decrease in cell proliferation of EAC and ESCC cell lines [73], whereas RNF113A knockdown resulted in reduced proliferation and increased apoptosis, as well as inhibition of the migratory and invasive capacities of ESCC cell lines and decreased tumour growth in nude mice [77]. This evidence concerns the gene RNF113A and esophageal squamous cell carcinoma.