Moreover, KDM4C/GASC1 (gene amplified in squamous cell carcinoma 1) was amplified and overexpressed in ESCC cell lines [151], whereas KDM5B/JARID1B (Jumonji at rich interactive domain 1B) was up-regulated in ESCC cell lines compared with normal oesophageal cells [152]. This evidence concerns the gene KDM5B and esophageal squamous cell carcinoma.