In the TCGA dataset, we found that ESCC displayed significantly higher KDM1A, KDM5B and KDM7C levels than EAC (Figure 2h and Figure S1); conversely, EAC showed KDM4C and KDM6A up-regulation in comparison with ESCC (Figure S1). The gene discussed is KDM4C; the disease is esophageal squamous cell carcinoma.