Although to a lesser extent, with only two genes assessed, the results for histone acetyltransferases resemble those obtained for HDACs, with KAT1B and KAT13B promoting the development of oesophageal cancer, both in cell lines and animal studies, and being up-regulated in oesophageal cancer tissues (Table 1). The gene discussed is NCOA3; the disease is carcinoma of esophagus.